Running a PHP server, in production, without a cache seems now quite unrealistic. You may now choose between APC, eAccelerator and XCache, all available in remi (or remi-test) repository, if you use PHP 5.3 or 5.4.
Of course, only one can be installed.
Installation, for Fedora, or Enterprise Linux with PHP 5.3
yum --enablerepo=remi install php-xcache
Installation, for Enterprise Linux with PHP 5.4
yum --enablerepo=remi,remi-test install php-xcache
According to tests and feedback, I will consider to submit it for official Fedora repository..